ABSTRACT

Porphyromonas. gingivalis (P. gingivalis)

is an obligate, asaccharolytic, gram-negative bacteria commonly associated with increased periodontal and systemic inflammation. P. gingivalis is known to survive and persist within the host tissues as it modulates the entire ecosystem by either engineering its environment or modifying the host’s immune response. It interacts with various host receptors and alters signaling pathways of inflammation, complement system, cell cycle, and apoptosis. P. gingivalis is even known to induce suicidal cell death of the host and other microbes in its vicinity with the emergence of pathobiont species. Recently, new molecular and immunological mechanisms and virulence factors of P. gingivalis that increase its chance of survival and immune evasion within the host have been discovered. Thus, the present paper aims to provide a consolidated update on the new intricate and unique molecular mechanisms and virulence factors of P. gingivalis associated with its survival, persistence, and immune evasion within the host.

中文翻译：

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牙龈卟啉单胞菌采用复杂而独特的分子机制在宿主体内生存和持久存在：一项重要更新。

 抽象的

卟啉单胞菌。牙龈炎 (P. gingivalis)

是一种专性解糖革兰氏阴性细菌，通常与牙周和全身炎症增加有关。众所周知，牙龈卟啉单胞菌可以在宿主组织内生存并持续存在，因为它通过改造其环境或改变宿主的免疫反应来调节整个生态系统。它与各种宿主受体相互作用并改变炎症、补体系统、细胞周期和细胞凋亡的信号传导途径。甚至已知牙龈卟啉单胞菌会随着致病生物物种的出现而诱导宿主及其附近其他微生物的自杀性细胞死亡。最近，人们发现了牙龈卟啉单胞菌新的分子和免疫学机制以及毒力因子，这些因子增加了其在宿主体内的生存和免疫逃避的机会。因此，本文旨在提供与牙龈卟啉单胞菌在宿主体内的生存、持久性和免疫逃避相关的新的复杂而独特的分子机制和毒力因子的综合更新。