ABSTRACT

Introduction

Between 5 and 25% of patients with cutaneous lupus erythematosus (CLE) can progress to systemic lupus erythematosus (SLE) during the course of the disease. There is no clear predictive guideline for the progression of CLE to SLE.

Areas covered

Lupus erythematosus (LE), a chronic autoimmune disease, has a wide spectrum of manifestations. On one side of the spectrum is CLE, in which patients only display skin lesions. On the other side of the spectrum is SLE, which develops severe systemic involvement. CLE has even been considered as a separate entity from LE, while CLE is also proposed to be associated with SLE. In this review, the authors will describe the relationship between CLE and SLE; summarize the incidence, risk factors, systemic involvement, and management of patients who transition to SLE. The literature search was conducted mainly through PubMed from March to July 2020.

Expert opinion

The identification of clinical characteristics and biomarkers in patients facing risk of developing SLE and monitoring the disease on a regular basis are essential to promptly manage and hopefully prevent transition to the systemic form.

中文翻译：

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对从皮肤狼疮到系统性红斑狼疮的进展的新见解。

摘要

介绍

5% 至 25% 的皮肤红斑狼疮 (CLE) 患者在疾病过程中会发展为系统性红斑狼疮 (SLE)。CLE 进展为 SLE 没有明确的预测指南。

覆盖区域

红斑狼疮（LE）是一种慢性自身免疫性疾病，具有广泛的表现。一方面是 CLE，其中患者仅表现出皮肤病变。另一方面是 SLE，它会发展为严重的全身受累。CLE 甚至被视为独立于 LE 的实体，而 CLE 也被提议与 SLE 相关联。在这篇综述中，作者将描述 CLE 和 SLE 之间的关系；总结过渡到 SLE 的患者的发病率、危险因素、全身受累和管理。2020 年 3 月至 7 月主要通过 PubMed 进行文献检索。

专家意见

识别面临患 SLE 风险的患者的临床特征和生物标志物并定期监测疾病对于及时管理并有望防止转变为全身性形式至关重要。