Magnetic γ-Fe₂O₃/CeO_x nanoparticles were obtained by basic coprecipitation/oxidation of iron chlorides with hydrogen peroxide, followed by precipitation of Ce(NO₃)₃ with ammonia. The appearance of CeO_x on the magnetic particle surface was confirmed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), and elemental analysis; a magnetometer was used to measure the magnetic properties of γ-Fe₂O₃/CeO_x. The relatively high saturation magnetization of the particles (41.1 A·m²/kg) enabled magnetic separation. The surface of γ-Fe₂O₃/CeO_x particles was functionalized with PEG-neridronate of two different molecular weights to ensure colloidal stability and biocompatibility. The ability of the particles to affect oxidative stress in hereditary hypertriglyceridemic (HHTg) rats was tested by biological assay of the liver, kidney cortex, and brain tissues. An improvement was observed in both enzymatic [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)] and non-enzymatic (reduced (GSH) and oxidized (GSSG) glutathione) levels of antioxidant defense and lipid peroxidation parameters [4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)]. The results corresponded with chemical determination of antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, proving that in the animal model γ-Fe₂O₃/CeO_x@PEG_2,000 nanoparticles effectively scavenged radicals due to the presence of cerium oxide, in turn decreasing oxidative stress. These particles may therefore have the potential to reduce disorders associated with oxidative stress and inflammation.

磁性了γ-Fe ₂ ö ₃ /铈_X纳米颗粒由氯化铁与过氧化氢的基本共沉淀/氧化，接着铈沉淀（NO获得₃）₃与氨。通过X射线光电子能谱（XPS），粉末X射线衍射（XRD）和元素分析来确认CeO _x在磁性粒子表面上的出现。磁力计是用来测量γ-Fe的磁特性₂ ö ₃ /铈_X。颗粒的较高的饱和磁化强度（41.1 A·m ² / kg）可以实现磁分离。的表面了γ-Fe ₂ ö₃ / CeO _x颗粒用两种不同分子量的PEG-神经氨酸酯官能化，以确保胶体稳定性和生物相容性。通过对肝，肾皮质和脑组织的生物学测定，测试了颗粒影响遗传性高甘油三酸酯（HHTg）大鼠中氧化应激的能力。酶促抗氧化防御和脂质过氧化参数的酶促[超氧化物歧化酶（SOD），过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）]和非酶促（还原（GSH）和氧化（GSSG）谷胱甘肽）水平均得到改善。 [4-羟基壬烯（4-HNE）和丙二醛（MDA）]。结果与基于2,2-二苯基-1-吡啶并肼基（DPPH）测定的抗氧化活性的化学测定相对应，证明在动物模型γ-Fe中₂ O ₃ / CeO _x @PEG _2,000纳米颗粒由于氧化铈的存在而有效地清除了自由基，从而降低了氧化应力。因此，这些颗粒可能具有减少与氧化应激和炎症相关的疾病的潜力。