The fibroblast growth factor (FGF) family polypeptides play key roles in promoting tissue regeneration and repair. FGF5 is strongly up-regulated in Schwann cells of the peripheral nervous system following injury; however, a role for FGF5 in peripheral nerve regeneration has not been shown up to now. In this report, we examined the expression of FGF5 and its receptors FGFR1-4 in Schwann cells of the mouse sciatic nerve following injury, and then measured the effects of FGF5 treatment upon cultured primary rat Schwann cells. By microarray and mRNA sequencing data analysis, RT-PCR, qPCR, western blotting and immunostaining, we show that FGF5 is highly up-regulated in Schwann cells of the mouse distal sciatic nerve following injury, and FGFR1 and FGFR2 are highly expressed in Schwann cells of the peripheral nerve both before and following injury. Using cultured primary rat Schwann cells, we show that FGF5 inhibits ERK1/2 MAP kinase activity but promotes rapid Schwann cell migration and adhesion via the upregulation of N-cadherin. Thus, FGF5 is an autocrine regulator of Schwann cells to regulate Schwann cell migration and adhesion.

成纤维细胞生长因子（FGF）家族多肽在促进组织再生和修复中起关键作用。损伤后，FGF5在周围神经系统的雪旺细胞中强烈上调；然而，迄今为止，尚未显示FGF5在周围神经再生中的作用。在此报告中，我们检查了损伤后小鼠坐骨神经雪旺细胞中FGF5及其受体FGFR1-4的表达，然后测量了FGF5处理对培养的原代大鼠雪旺细胞的影响。通过芯片和mRNA测序数据分析，RT-PCR，qPCR，western blotting和免疫染色，我们发现FGF5在损伤后小鼠坐骨神经末梢的雪旺氏细胞中高度上调，而FGFR1和FGFR2在雪旺氏细胞中高表达受伤前后周围神经的损伤。通过N-钙黏着蛋白的上调。因此，FGF5是雪旺氏细胞的自分泌调节剂，以调节雪旺氏细胞的迁移和粘附。