The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.

中文翻译：

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医药应用的超临界抗溶剂工艺：综述

超临界抗溶剂（SAS）技术已广泛用于生物医学领域，包括药物输送，以获得纳米或微米尺寸的药物颗粒或基于聚合物的系统。产生SAS颗粒的主要目的是改善对不同病理的治疗，并改善患者的依从性。在这种情况下，许多活性化合物已被微粉化以提高其溶解速度和生物利用度。为了更有效的治疗并减少药物过量引起的副作用，主要提出了SAS聚合物/活性成分共沉淀为特定治疗提供足够的药物释放。减少对患者健康的副作用的新制剂的需求仍在增长；在这种情况下，SAS技术是解决生物医学领域现有问题的有前途的工具。有关在临床应用中使用SAS程序的最新评论，提供了有关成就，最有效的聚合物载体和参数以及未来前景的有用信息。