The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence of pathogenic strains harboring enhanced armors against existing therapeutics. Compromised the treatment regime of a broad range of antibiotics, rise in resistance has threatened human health and increased the treatment cost of diseases. Diverse on metabolic, genetic and physiological fronts, rapid progression of resistant microbes and the lack of a strategic management plan have led researchers to consider plant-derived substances (PDS) as alternative or in complementing antibiotics against the diseases. Considering the quantitative characteristics of plant constituents that attribute health beneficial effects, analytical procedures for their isolation, characterization and phytochemical testing for elucidating ethnopharmacological effects has being worked out for employment in the treatment of different diseases. With an immense potential to combat bacterial infections, PDSs such as polyphenols, alkaloids and tannins, present a great potential for use, either as antimicrobials or as antibiotic resistance modifiers. The present study focuses on the mechanisms by which PDSs help overcome the surge in resistance, approaches for screening different phytochemicals, methods employed in the identification of bioactive components and their testing and strategies that could be adopted for counteracting the lethal consequences of multidrug resistance.

中文翻译：

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以植物为基础的植物化学物质作为对抗细菌耐药性的抗生素的可能替代品。


抗生素的前所未有的使用导致了耐药性的产生，影响了全世界人类的健康。随着抗生素抗性微生物的获得和发展，在不同疾病中轻率和不合理地使用抗生素处方不断发展，导致对现有疗法具有更强防御力的致病菌株的复活。多种抗生素的治疗方案受到影响，耐药性的增加威胁着人类健康并增加了疾病的治疗成本。代谢、遗传和生理方面的多样性、耐药微生物的快速发展以及战略管理计划的缺乏导致研究人员考虑将植物源物质（PDS）作为针对疾病的替代或补充抗生素。考虑到植物成分对健康有益的定量特征，已制定出用于其分离、表征和植物化学测试的分析程序，以阐明民族药理学作用，以用于治疗不同的疾病。多酚、生物碱和单宁等 PDS 具有对抗细菌感染的巨大潜力，无论是作为抗菌剂还是作为抗生素耐药性调节剂，都具有巨大的使用潜力。本研究重点关注PDS帮助克服耐药性激增的机制、筛选不同植物化学物质的方法、鉴定生物活性成分的方法及其测试以及可用于抵消多药耐药性致命后果的策略。