Protein neddylation, one of the most important posttranslational modifications that tagging neuronal precursor cell‐expressed developmentally downregulated protein 8 onto substrate proteins, plays fundamental roles in the process of many cellular functions. A number of studies have demonstrated the critical roles of neddylation modification in multiple pathophysiological processes, but its regulatory role in the immune system has only been finitely unveiled.

中文翻译：

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neddylation 通路在免疫调节中的关键作用。

蛋白质 neddylation 是最重要的翻译后修饰之一，可将神经元前体细胞表达的发育下调蛋白 8 标记到底物蛋白上，在许多细胞功能的过程中发挥着重要作用。许多研究已经证明了 neddylation 修饰在多个病理生理过程中的关键作用，但其在免疫系统中的调节作用仅被有限地揭示。