Plasmodium chabaudi ‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract,Letters in Applied Microbiology

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Plasmodium chabaudi ‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-09-11 , DOI: 10.1111/lam.13366
S Al-Quraishy ₁ , M Murshed ₁ , D Delic ₂ , E M Al-Shaebi ₁ , M A A Qasem ₁ , M M Mares ₁ , M A Dkhil _{1,

3}

Affiliation

Malaria is a worldwide serious‐threatening infectious disease caused by Plasmodium and the parasite resistance to antimalarial drugs has confirmed a significant obstacle to novel therapeutic antimalarial drugs. In this article, we assessed the antioxidant and anti‐inflammatory activity of nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the infection with Plasmodium chabaudi caused in mice spleen. AgNPs could significantly suppress the parasitaemia caused by the parasite to approximately 98% on day 7 postinfection with P. chabaudi and could improve the histopathological induced spleen damage. Also, AgNPs were able to increase the capsule thickness of the infected mice spleen. In addition, the AgNPs functioned as an antioxidant agent that affects the change in glutathione, nitric oxide and catalase levels in the spleen. Moreover spleen IL1β, IL‐6 and TNF‐α‐mRNA expression was regulated by AgNPs administration to the infected mice. These results indicated the anti‐oxidant and the anti‐inflammatory protective role of AgNPs against P. chabaudi‐induced spleen injury.

中文翻译：

沙包地疟原虫感染小鼠脾脏对长叶绦虫提取物合成银纳米颗粒的反应

疟疾是由疟原虫引起的全球性严重威胁传染病，寄生虫对抗疟药的耐药性已证实是开发新型抗疟药的重大障碍。在这篇文章中，我们评估了由圆叶靛蓝提取物 (AgNPs) 制备的纳米颗粒对小鼠脾脏引起的沙包疟原虫感染的抗氧化和抗炎活性。在 P. chabaudi 感染后第 7 天，AgNPs 可以显着抑制由寄生虫引起的寄生虫血症至约 98%，并可以改善组织病理学诱导的脾脏损伤。此外，AgNPs 能够增加受感染小鼠脾脏的胶囊厚度。此外，AgNPs 作为一种抗氧化剂，影响脾脏中谷胱甘肽、一氧化氮和过氧化氢酶水平的变化。此外，脾脏 IL1β、IL-6 和 TNF-α-mRNA 的表达受感染小鼠的 AgNPs 的调节。这些结果表明 AgNPs 对 P. chabaudi 诱导的脾脏损伤具有抗氧化和抗炎保护作用。

更新日期：2020-09-11

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