What happens when two emergent diseases infect the same host? In a From the Cover article in this issue of Molecular Ecology, McDonald et al. (2020) compare transcriptomic responses to co‐infection by the two chytrid fungi in the skin, liver and spleen of Eastern newts (Notophthalmus viridescens). Novel molecular tools, such as high‐throughput DNA sequencing for genome discovery and transcriptomics, have revolutionized our understanding of host–pathogen interactions and disease ecology (Güimil et al. 2005; Rosenblum et al. 2012). For example, epidemiologists are using genomic data to track the spread of the emergent SARS‐CoV‐2 in real time, both locally and globally. RNA sequencing (RNA‐Seq) is routinely employed to study response to disease in humans, improving disease diagnostics, profiling and development of intervention strategies. Transcriptomic profiles may be particularly informative for emergent diseases, whose pathologies and effect on host phenotype are poorly known. Fungal pathogens increasingly threaten a variety of wild and domesticated organisms (Fisher et al. 2012), and two chytrid fungi attacking amphibians are causing one of the worst losses of vertebrate biodiversity ever recorded (Scheele et al. 2019).

中文翻译：

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转录组学揭示了糜蛋白酶共感染淹没的new的免疫下调。

当两种突发疾病感染同一宿主时会发生什么？在本期《分子生态学》的封面文章中，McDonald等人。（2020年）比较了东部new（Notophthalmus viridescens）在皮肤，肝脏和脾脏中两种乳糜真菌对共感染的转录反应）。新型分子工具，例如用于基因组发现和转录组学的高通量DNA测序，彻底改变了我们对宿主-病原体相互作用和疾病生态学的理解（Güimil等，2005； Rosenblum等，2012）。例如，流行病学家正在使用基因组数据来实时追踪本地和全球新兴SARS-CoV-2的传播。RNA测序（RNA‐Seq）通常用于研究人类对疾病的反应，改善疾病诊断，分析和制定干预策略。转录组概况可能对紧急疾病尤其有用，因为其疾病和对宿主表型的影响尚不清楚。真菌病原体越来越多地威胁着各种野生和驯化生物（Fisher等，2012），