Copper‐Catalyzed Aerobic Oxidative Ring Expansion of Isatins: A Facile Entry to Isoquinolino‐Fused Quinazolinones,Chinese Journal of Chemistry

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Copper‐Catalyzed Aerobic Oxidative Ring Expansion of Isatins: A Facile Entry to Isoquinolino‐Fused Quinazolinones
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-08-03 , DOI: 10.1002/cjoc.202000368
Dahan Wang ₁ , Fuhong Xiao ₁ , Feng Zhang _{1,

2} , Huawen Huang ₁ , Guo‐Jun Deng ₁

Affiliation

A copper‐catalyzed aerobic oxidative ring expansion reaction of isatins with 1,2,3,4‐tetrahydroisoquinoline for the synthesis of tetracyclic quinazolinones has been developed. This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields with good functional group tolerance. The capacity of the resultant 5H‐isoquinolino[1,2‐b]quinazolin‐8(6H)‐one for a range of palladium‐catalyzed directing C—H activation has been further demonstrated, thus giving a broader access to diverse tetracyclic quinazolinones.

中文翻译：

铜催化的Isatin的有氧氧化环扩展：异喹啉基融合的喹唑啉酮类的便捷入门

已经开发了一种铜的伊斯替丁与1,2,3,4-四氢异喹啉催化的好氧氧化环膨胀反应，用于合成四环喹唑啉酮。该反应在简单条件下顺利进行，以中等至良好的产率得到具有良好官能团耐受性的相应产物。进一步证明了所得的5 H-异喹啉基[1,2- b ]喹唑啉-8（6 H）-one在一系列钯催化的CH活化中的能力，因此可以更广泛地使用各种四环化合物喹唑啉酮。

更新日期：2020-08-03

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