Poly(l‐lactic) acid (PLLA) is widely used in guided bone regeneration membranes due to its mechanical properties and biodegradability. However, the lack of biocompatibility is a serious disadvantage. Herein, the biocompatibility of PLLA is improved by patterning hydroxyapatite (HA) loaded with recombinant human bone morphogenetic protein‐2 (rhBMP‐2) under it. The HA is obtained by preparing a magnesium pattern via photolithography and hydrothermal converting. After loading rhBMP‐2, the pattern is transferred to PLLA. The pattern is tightly embedded in the PLLA and retained its original position after mechanical stimuli. Fluorescence images allow to assess the protein adsorption and gradual release in a controlled manner. The amount of released rhBMP‐2 is overwhelmingly large when loaded under HA because of its large surface area. Osteogenic differentiation supports the synergistic effect of HA and rhBMP‐2 to improve the biocompatibility. Moreover, in vivo experiments demonstrate that the synergistic effect positively affects the healing rate of bone.

中文翻译：

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具有嵌入式羟基磷灰石模式的 PLLA 膜，可提高生物活性并有效输送生长因子。

聚( l乳酸 (PLLA) 由于其机械性能和生物降解性而广泛用于引导骨再生膜。然而，缺乏生物相容性是一个严重的缺点。在此，PLLA 的生物相容性通过在羟基磷灰石（HA）下负载重组人骨形态发生蛋白-2（rhBMP-2）的模式化得到改善。HA是通过光刻和水热转化制备镁图案获得的。加载 rhBMP-2 后，模式被转移到 PLLA。该图案紧密嵌入 PLLA 并在机械刺激后保持其原始位置。荧光图像允许以受控方式评估蛋白质吸附和逐渐释放。由于其大的表面积，当加载在 HA 下时，释放的 rhBMP-2 的量非常大。成骨分化支持 HA 和 rhBMP-2 的协同作用，以提高生物相容性。此外，体内实验表明协同效应对骨愈合率有积极影响。