Synthesis of calcium‐layered double hydroxide based nanohybrid for controlled release of an anti‐inflammatory drug,Journal of the Chinese Chemical Society

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Synthesis of calcium‐layered double hydroxide based nanohybrid for controlled release of an anti‐inflammatory drug
Journal of the Chinese Chemical Society ( IF 1.6 ) Pub Date : 2020-08-04 , DOI: 10.1002/jccs.202000008
Milad Abniki ₁ , Ali Moghimi ₁ , Fariborz Azizinejad ₁

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The study proposed an approach for synthesis‐Layered Double Hydroxide nanoparticles by the coprecipitation method in solution containing two divalent and trivalent metal salts, calcium, and aluminum. The synthesized calcium‐layered Double Hydroxide (CAL) used for intercalating an anti‐inflammatory drug with the purpose of obtaining controlling release rate, protecting of drug from decomposition and raising the poor aqueous solubility of drug. Mefenamic acid (ME) as anti inflammatory drug was intercalated into CAL from ion‐exchange route to preparation CAL/ME nanohybrids. An increase in the space of interlayer of the (002) plane from 8.06 Å in pristine CAL to 34.51 Å in the nanohybrid confirmed successful intercalation of ME anion into CAL framework, which was ordered in a bilayer fashion with the carboxylate functional groups in the interlayer gallery of CAL. The x‐ray diffraction and FTIR study indicated that the ME was successfully intercalated into interlayer space of CAL. The chemical composition of samples was evaluated by ICP‐OES and energy‐dispersive spectrum analysis. TG analysis confirmed that the thermal stability of intercalated ME in the form of nanohybrid was enhanced. dynamic light scattering and field emission scanning electron microscopy were determined the size of CAL particles. Finally, in vitro drug release experiments of nanohybrid at a PH of 4.8 and 7.4 showed sustained release profiles with ME anions as an anti‐inflammatory model drug.

中文翻译：

钙层双氢氧化物基纳米杂合物的合成以控制消炎药的释放

该研究提出了一种通过共沉淀法在含有两种二价和三价金属盐，钙和铝的溶液中合成层状双氢氧化物纳米粒子的方法。合成的钙层双氢氧化物（CAL）用于插入抗炎药，目的是获得控制释放速率，防止药物分解和增加不良的水溶性。从离子交换途径到制备CAL / ME纳米杂化物，将甲芬那酸（ME）作为抗炎药插入CAL中。（002）平面的中间层空间从原始CAL中的8.06Å增加到纳米杂化物中的34.51Å，证实了ME阴离子已成功插入CAL骨架中，它以双层形式与CAL的夹层通道中的羧酸酯官能团一起订购。X射线衍射和FTIR研究表明，ME已成功插入CAL的层间空间。样品的化学成分通过ICP-OES和能谱分析进行了评估。TG分析证实，以纳米杂化形式插入的ME的热稳定性得到增强。动态光散射和场发射扫描电子显微镜确定了CAL颗粒的大小。最后，在4.8和7.4的PH值下进行的纳米杂合体的体外药物释放实验显示，ME阴离子作为抗炎模型药物具有持续释放的特性。样品的化学成分通过ICP-OES和能谱分析进行了评估。TG分析证实，以纳米杂化形式插入的ME的热稳定性得到增强。动态光散射和场发射扫描电子显微镜确定了CAL颗粒的大小。最后，在4.8和7.4的PH值下进行的纳米杂合体的体外药物释放实验显示，ME阴离子作为抗炎模型药物具有持续释放的特性。样品的化学成分通过ICP-OES和能谱分析进行了评估。TG分析证实，以纳米杂化形式插入的ME的热稳定性得到增强。动态光散射和场发射扫描电子显微镜确定了CAL颗粒的大小。最后，在4.8和7.4的PH值下进行的纳米杂合体的体外药物释放实验显示，ME阴离子作为抗炎模型药物具有持续释放的特性。

更新日期：2020-08-04

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