The beneficial effects of light‐emitting diode (LED) irradiation have been reported in various pathologies, including cancer. However, its effect in pancreatic cancer cells remains unclear. Herein, we demonstrated that blue LED of 460 nm regulated pancreatic cancer cell proliferation and apoptosis by suppressing the expression of apoptosis‐related factors, such as mutant p53 and B‐cell lymphoma 2 (Bcl‐2), and decreasing the expression of RAC‐β serine/threonine kinase 2 (AKT2), the phosphorylation of protein kinase B (AKT), and mammalian target of rapamycin (mTOR). Blue LED irradiation also increased the levels of cleaved poly‐(ADP‐ribose) polymerase (PARP) and caspase‐3 in pancreatic cancer cells, while it suppressed AKT2 expression and inhibited tumor growth in xenograft tumor tissues. In conclusion, blue LED irradiation suppressed pancreatic cancer cell and tumor growth by regulating AKT/mTOR signaling. Our findings indicated that blue LEDs could be used as a nonpharmacological treatment for pancreatic cancer.

中文翻译：

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发光二极管照射在人胰腺癌细胞和异种移植小鼠模型中诱导 AKT/mTOR 介导的细胞凋亡。

已经报道了发光二极管 (LED) 照射在各种病理中的有益作用，包括癌症。然而，其在胰腺癌细胞中的作用仍不清楚。在此，我们证明了 460 nm 的蓝色 LED 通过抑制凋亡相关因子（如突变 p53 和 B 细胞淋巴瘤 2（Bcl-2）的表达以及降低 RAC- β 丝氨酸/苏氨酸激酶 2 (AKT2)、蛋白激酶 B (AKT) 的磷酸化和哺乳动物雷帕霉素靶标 (mTOR)。蓝光 LED 照射还增加了胰腺癌细胞中裂解的聚（ADP-核糖）聚合酶（PARP）和 caspase-3 的水平，同时它抑制了 AKT2 表达并抑制了异种移植肿瘤组织中的肿瘤生长。综上所述，蓝光 LED 照射通过调节 AKT/mTOR 信号传导抑制胰腺癌细胞和肿瘤生长。我们的研究结果表明，蓝色 LED 可用作胰腺癌的非药物治疗。