Soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) proteins are a large protein complex that is involved in the membrane fusion in vesicle trafficking, cell growth, cytokinesis, membrane repair, and synaptic transmission. As one of the SNARE proteins, SEC22B functions in membrane fusion of vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus, antigen cross‐presentation, secretory autophagy, and other biological processes. However, apart from not being SNARE proteins, there is little knowledge known about its two homologs (SEC22A and SEC22C). SEC22B alterations have been reported in many human diseases, especially, many mutations of SEC22B in human cancers have been detected. In this review, we will introduce the specific functions of SEC22B, and summarize the researches about SEC22B in human cancers and other diseases. These findings have laid the foundation for further studies to clarify the exact mechanism of SEC22B in the pathological process and to seek new therapeutic targets and better treatment strategies.

中文翻译：

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SEC22B 的功能及其在人类疾病中的作用。

可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体 (SNARE) 蛋白是一种大型蛋白质复合物，参与囊泡运输、细胞生长、胞质分裂、膜修复和突触传递中的膜融合。作为 SNARE 蛋白之一，SEC22B 在内质网和高尔基体之间的囊泡运输、抗原交叉呈递、分泌自噬和其他生物过程的膜融合中起作用。然而，除了不是 SNARE 蛋白之外，对其两个同源物（SEC22A 和 SEC22C）知之甚少。已经在许多人类疾病中报道了 SEC22B 改变，尤其是在人类癌症中检测到了许多 SEC22B 突变。在这篇综述中，我们将介绍 SEC22B 的具体功能，并总结SEC22B在人类癌症和其他疾病中的研究。这些发现为进一步研究阐明SEC22B在病理过程中的确切机制，寻找新的治疗靶点和更好的治疗策略奠定了基础。