Cystine/glutamic acid reverse transporter (System X_c⁻), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11), which promotes cystine uptake and glutathione biosynthetic, thus protecting against oxidative stress and ferroptosis. Studies have confirmed that xCT is highly expressed in a variety of tumour and is associated with tumour proliferation, invasion, metastasis, drug resistance and ferroptosis, and can be used as a potential target for tumour treatment. This review provides insights into the biological effects of xCT and contribute to the development of new xCT‐based strategies.

中文翻译：

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胱氨酸谷氨酸逆转运蛋白xCT作为癌症的治疗靶标

胱氨酸/谷氨酸反向转运体（系统X _Ç ^- ），氨基酸转运蛋白家族的一个成员，包括两个亚基，轻链XCT链和重链的4F2hc。xCT是胱氨酸/谷氨酸逆向转运蛋白溶质载体家族7成员11（SLC7A11），它促进胱氨酸的摄取和谷胱甘肽的生物合成，从而防止氧化应激和肥大症。研究已经证实，xCT在多种肿瘤中高表达，并且与肿瘤增殖，侵袭，转移，耐药性和肥大症有关，并且可以用作潜在的肿瘤治疗靶标。这篇综述提供了xCT生物学效应的见解，并为基于xCT的新策略的开发做出了贡献。