Peste des Petits Ruminants (PPR) is an acute, highly contagious, economically important transboundary viral disease of small ruminants. The objectives of this cross-sectional study were to estimate the seroprevalence and associated risk factors of PPR in small ruminants in selected districts of Horo Guduru Zone, Western Ethiopia. A total of 806 blood samples, corresponding to 124 flocks comprised of 387 sheep and 419 goats, were collected using multi-stage sampling. The sera were tested using competitive Enzyme-Linked Immunosorbent Assay (c-ELISA). A pre-tested questionnaire was used to collect data on potential risk factors for PPRV infection. Pearson's Chi-Square and logistic regression analyses were used to see the association of the seroprevalence with potential risk factors. The flock-level overall seroprevalence of PPR was 27.42% (95% confidence interval [CI]: 19.79–36.15%). An overall animal level seroprevalence of 5.71% (95% CI: 4.21–7.54%) was recorded with 6.98% (95% CI: 4.65–10.00%) seroprevalence in sheep and 4.53% (95% CI: 2.75–6.99%) in goats. There was a significant association between the seroprevalence and risk factors that were sharing common grazing land (P = 0.032), the introduction of newly purchased animals into the flock (P = 0.011), and uncontrolled animal movements in goats (P = 0.018). Sharing common grazing land with other flocks in goats (P = 0.026) and midland altitude in sheep (P = 0.029) were the other predictors of PPR. The seropositivity in unvaccinated small ruminants suggests the circulation of the virus. Therefore, awareness creation, vaccination, strengthening the disease surveillance system and large-scale epidemiological and molecular studies are suggested.

小反刍兽疫（PPR）是一种急性，高度传染性，经济上重要的小反刍动物跨界病毒病。这项横断面研究的目的是估计埃塞俄比亚西部Horo Guduru地区某些地区的小反刍动物的PPR血清阳性率及其相关危险因素。使用多阶段采样，总共收集了806个血液样本，对应于由387只绵羊和419只山羊组成的124个鸡群。使用竞争性酶联免疫吸附测定（c-ELISA）测试血清。使用预先测试的问卷收集有关PPRV感染的潜在危险因素的数据。皮尔逊（Pearson）的卡方（chi-Square）和logistic回归分析用于观察血清阳性率与潜在危险因素之间的关系。PPR的鸡群总体血清阳性率为27。42％（95％置信区间[CI]：19.79-36.15％）。记录的动物总体血清阳性率为5.71％（95％CI：4.21-7.54％），绵羊为6.98％（95％CI：4.65-10.00％），而绵羊为4.53％（95％CI：2.75-6.99％）。山羊。血清共患病率与共享共同放牧地的危险因素之间存在显着关联（P  = 0.032），将新购买的动物引入羊群（P  = 0.011），以及山羊不受控制的动物活动（P  = 0.018）。 PPR的其他预测指标是与山羊的其他羊群共享公共牧场（P  = 0.026）和绵羊的中部海拔高度（P = 0.029）。未接种疫苗的小反刍动物的血清阳性表明该病毒的传播。因此，建议提高意识，进行疫苗接种，加强疾病监测系统以及大规模的流行病学和分子研究。