Degradation of scaffolds is an important requirement for their applications in tissue engineering. The degradation rate should match the regeneration rate of growing tissue; therefore, controlling the degradation rate is considered as an important parameter in scaffold designing. In the present study, ciprofloxacin-loaded zein/Polyvinylpyrrolidone (PVP) based conduits were prepared using a facile method. Conduits were prepared with different amounts of PVP (2–32%), while fixed amounts of zein and ciprofloxacin were used. Conduits were evaluated for morphological analysis, porosity, mechanical strength, ciprofloxacin release, antibacterial efficacy, cytocompatibility, and in vitro/in vivo degradation. Conduits showed better bending stiffness (8.6–31.6 N mm²) and controlled porosity (66.3–88.7%). A controllable degradation rate could be achieved which was dependent on the amount of PVP. Conduits with higher PVP amount degraded faster than those of having lower PVP. Furthermore, the release dynamics of ciprofloxacin was also found to be dependent upon the amount of PVP and showed tunable behavior, as fitted by different drug-release models. As expected, the in vivo implantation in SD rats showed that the degradation of the conduits using 32% PVP as a porogen was hastened significantly. Overall, the zein/PVP conduits exhibited a tunable degradation rate and drug release.

支架的降解是对其在组织工程中的应用的重要要求。降解速率应与生长组织的再生速率匹配；因此，控制降解速率被认为是支架设计中的重要参数。在本研究中，使用简便的方法制备了载有环丙沙星的玉米蛋白/聚乙烯吡咯烷酮（PVP）基导管。用不同数量的PVP（2-32％）制备导管，同时使用固定量的玉米醇溶蛋白和环丙沙星。对导管进行形态分析，孔隙率，机械强度，环丙沙星释放，抗菌功效，细胞相容性和体内/体外降解评估。管道显示出更好的弯曲刚度（8.6–31.6 N mm ²）和控制的孔隙度（66.3–88.7％）。取决于PVP的量，可以实现可控制的降解速率。PVP含量较高的导管比PVP含量较低的导管降解更快。此外，还发现环丙沙星的释放动力学取决于PVP的量并显示出可调的行为，这与不同的药物释放模型相符。不出所料，在SD大鼠体内植入表明，使用32％PVP作为致孔剂可以显着加快导管的降解。总体而言，玉米醇溶蛋白/ PVP导管表现出可调节的降解速率和药物释放。