Abstract Cancer is a very risky life-threatening disease having most formidable afflictions in the world. Several anticancer agents are commercially accessible, however, the emergence of acquired drug resistance along with extreme adverse effects of these clinically used anticancer medications are major barriers to the effective chemotherapy. Thus, it is recommended to rationally design the newer drugs with few side effects. Fluoroquinolone derivatives are of pivotal interest for researchers due to their admirable pharmacological and pharmacokinetic profiles. They exhibit several favourable characteristics including, higher bioavailability, excellent tissue penetration and relatively low prevalence of adverse and toxic effects. Due to their potential interventions in carcinogenesis and mutagenesis, the focus of the area of research is nowadays shifting towards anticancer aspects of these compounds. This review shows the recent advancements in the development of novel fluoroquinolones as potential anticancer and cytotoxic agents and structure-activity relationships along with the possible modes of action for further development and recent patents filed/granted related to anticancer activity from the last few years have also been tabulated. Also, this review is an attempt to focus on the various upcoming aspects of fluoroquinolones and provides a newer outlook on the possible roles of fluoroquinolones in the treatment of cancer. Scientific information identified in this paper is expected to be useful for aspiring researchers working on the anticancer activity of fluoroquinolones.

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氟喹诺酮类药物在癌症治疗中的见解：化学和最新进展

摘要 癌症是一种非常危险的危及生命的疾病，是世界上最可怕的疾病。几种抗癌药物可在商业上获得，然而，获得性耐药性的出现以及这些临床使用的抗癌药物的极端不良反应是有效化疗的主要障碍。因此，建议合理设计副作用少的新型药物。氟喹诺酮衍生物因其令人钦佩的药理学和药代动力学特征而受到研究人员的关注。它们表现出几个有利的特性，包括更高的生物利用度、出色的组织渗透性和相对较低的不良和毒性作用发生率。由于它们对致癌和诱变的潜在干预，如今，研究领域的重点正在转向这些化合物的抗癌方面。本综述显示了新型氟喹诺酮类药物作为潜在抗癌剂和细胞毒剂的最新进展、结构-活性关系以及进一步开发的可能作用方式以及最近几年提交/授予的与抗癌活性相关的专利被列出。此外，本综述试图关注氟喹诺酮类药物即将出现的各个方面，并对氟喹诺酮类药物在癌症治疗中的可能作用提供了新的观点。本文中确定的科学信息有望对有抱负的研究氟喹诺酮类药物抗癌活性的研究人员有用。本综述显示了新型氟喹诺酮类药物作为潜在抗癌剂和细胞毒剂的最新进展、结构-活性关系以及进一步开发的可能作用方式以及最近几年提交/授予的与抗癌活性相关的专利被列出。此外，本综述试图关注氟喹诺酮类药物即将出现的各个方面，并对氟喹诺酮类药物在癌症治疗中的可能作用提供了新的观点。本文中确定的科学信息有望对有抱负的研究氟喹诺酮类药物抗癌活性的研究人员有用。本综述显示了新型氟喹诺酮类药物作为潜在抗癌剂和细胞毒剂的最新进展、结构-活性关系以及进一步开发的可能作用方式以及最近几年提交/授予的与抗癌活性相关的专利被列出。此外，本综述试图关注氟喹诺酮类药物即将出现的各个方面，并对氟喹诺酮类药物在癌症治疗中的可能作用提供了新的观点。本文中确定的科学信息有望对有抱负的研究氟喹诺酮类药物抗癌活性的研究人员有用。