The aim of the present work is fabrication of dual cross linked sodium alginate (SA)/montmorillonite (MMT) microbeads as a potential drug vehicle for extended release of curcumin (CUR). The microbeads were prepared using in situ ion-exchange followed by simple ionotropic gelation technique. The developed beads were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD) and scanning electron microscopy (SEM). The effect of MMT on encapsulation efficiency of CUR and intercalation kinetics was investigated. Dynamic swelling study and in vitro release study were investigated in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results suggested that both the swelling and in vitro release studies were influenced by the pH of test media, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into Korsmeyer-Peppas equation.

本工作的目的是制造双交联海藻酸钠 (SA)/蒙脱土 (MMT) 微珠，作为姜黄素 (CUR) 缓释的潜在药物载体。使用原位离子交换和简单的离子型凝胶技术制备微珠。通过傅里叶变换红外光谱 (FTIR)、差示扫描量热法 (DSC)、热重分析 (TGA)、X 射线衍射 (X-RD) 和扫描电子显微镜 (SEM) 对开发的珠子进行了表征。研究了 MMT 对 CUR 的封装效率和嵌入动力学的影响。在 37 °C 下对模拟肠液 (pH 7.4) 和模拟胃液 (pH 1.2) 进行动态肿胀研究和体外释放研究。结果表明，溶胀和体外释放研究均受测试介质 pH 值的影响，这可能适用于肠道给药。通过将释放数据拟合到 Korsmeyer-Peppas 方程来分析释放机制。