This study investigated effects of triterpenoids derived from Ganoderma lucidum (GLT) on the ability to attenuate cognitive impairment and reduce oxidative stress and inflammation induced by D-galactose using an aged rats model. The data revealed that dietary GLT intervention improved the memory of aged rats in a water maze experiment. A reduction in inflammation was also achieved as GLT decreased the levels of MDA, AGEs, NO, TNF-α and AChE activity, and increased the activity of T-AOC, GSH-Px, T-SOD, CAT and IL-2 level in serum. The GLT intervention revised hepatocyte cellular arrangement and binucleation of the liver status, and even hippocampal neurons morphology. GLT upregulated the expression of FOXO4, SIRT1, and downregulated the expression of GFAP, iNOS, PI3K, AKT, mTOR and IL-6 with activation of PI3K/AKT/mTOR pathway. The current study highlights a promising dietary approach for prevention or alleviation of oxidative stress, inflammation and cognitive impairment induced by age-related conditions.

这项研究使用老年大鼠模型研究了灵芝衍生的三萜类化合物对减轻认知障碍，减轻D-半乳糖诱导的氧化应激和炎症的能力的影响。数据显示，饮食中的GLT干预可以改善水迷宫实验中衰老大鼠的记忆力。由于GLT降低了MDA，AGEs，NO，TNF-α和AChE活性的水平，并提高了T-AOC，GSH-Px，T-SOD，CAT和IL-2的水平，炎症也得以减轻。血清。GLT干预修改了肝细胞的细胞排列和肝脏的双核状态，甚至是海马神经元的形态。GLT上调FOXO4和SIRT1的表达，并下调GFAP的表达，iNOS，PI3K，AKT，mTOR和IL-6具有PI3K / AKT / mTOR途径的激活。当前的研究强调了一种有前途的饮食方法，可以预防或减轻与年龄有关的疾病引起的氧化应激，炎症和认知障碍。