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Approach on chitosan/virgin coconut oil-based emulsion matrices as a platform to design superabsorbent materials.
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2020-08-04 , DOI: 10.1016/j.carbpol.2020.116839
Simone S Silva 1 , Luísa C Rodrigues 1 , Emanuel M Fernandes 1 , Joana M Gomes 1 , Ângela Vilas-Boas 1 , Rogério P Pirraco 1 , Rui L Reis 2
Affiliation  

The design of innovative pharmaceutical products, able to reach unexplored market niches, requires natural materials use with improved swelling and moisture properties. Herein, chitosan (CHT), a natural polymer, was combined with virgin coconut oil (VCO), a resource extracted from coconut kernels, to develop emulsion-based films for biomedical purposes. The film's properties were tuned by changing VCO concentrations, and the structural, morphological, and physical properties of the films were evaluated. The CHT/VCO-based film morphology showed the presence of VCO droplets at different sizes, both in the surface and inner part. Moreover, the capability to develop CHT/VCO-films as superabsorbent materials was shown. The film extracts cytotoxicity was assessed using human adipose stem cells, and metabolic activity was confirmed. The findings suggest that incorporating a small volume of VCO into the CHT system, superabsorbent materials with the potential to be applied in biomedical devices that require high swelling properties, can be developed.



中文翻译:

以壳聚糖/原始椰子油基乳液基质为平台设计超吸收性材料的方法。

能够到达未开发市场利基市场的创新药物产品的设计,需要使用天然材料并具有改善的溶胀和保湿性能。在此,将天然聚合物壳聚糖(CHT)与从椰子仁中提取的原始椰子油(VCO)混合,以开发用于生物医学目的的乳液型薄膜。通过改变VCO浓度来调整薄膜的性能,并评估薄膜的结构,形态和物理性能。基于CHT / VCO的薄膜形态表明,在表面和内部均存在不同尺寸的VCO液滴。此外,显示了开发CHT / VCO薄膜作为超吸收材料的能力。使用人脂肪干细胞评估膜提取物的细胞毒性,并确认代谢活性。

更新日期:2020-08-04
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