Wound dressings based on injectable thermo-sensitive hydrogel possess several advantages over preformed conventional dressings such as rapid reversible sol-gel transition behavior and the capacity of filling the irregular wound defect. Nevertheless, its clinical application is hindered by the weak tissue adhesiveness. Therefore, in this study, the catechol modified quaternized chitosan (QCS-C) was fabricated and incorporated into poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PLEL) hydrogel to develop an injectable hydrogel with the properties of thermo-sensitive, antibacterial and tissue adhesive. QCS-C could lower the LCST of hydrogel for easy gelation at physiological temperature, and significantly enhanced the tissue adhesion. For wound generation, nano-scaled bioactive glass (nBG：80 SiO₂, 16 CaO and 4 P₂O₅; mol%) was loaded into hydrogel to promote angiogenesis. The mice partial laceration experiment showed that PLEL-nBG-QCS-C hydrogel could effectively seal the ruptured skin and significantly accelerate wound healing. Thus, our findings established a new type of clinical treatment technology for complicated wounds.

基于可注射的热敏水凝胶的伤口敷料相对于预制的常规敷料具有多个优点，例如快速可逆的溶胶-凝胶转变行为和填充不规则伤口缺陷的能力。然而，其临床应用受到薄弱的组织粘附性的阻碍。因此，在本研究中，制备了邻苯二酚改性的季铵化壳聚糖（QCS-C），并掺入到聚（d，l-丙交酯）-聚（乙二醇）-聚（d，l-丙交酯）（PLEL）水凝胶中以进行开发具有热敏，抗菌和组织粘合剂特性的可注射水凝胶。QCS-C可以降低水凝胶的LCST，从而在生理温度下易于胶凝，并显着增强组织粘附力。用于创面的纳米级生物活性玻璃（nBG：80 SiO ₂，16 CaO和4 P ₂ O ₅ ; mol％）装入水凝胶以促进血管生成。小鼠局部裂伤实验表明，PLEL-nBG-QCS-C水凝胶可以有效地密封破裂的皮肤并显着加速伤口愈合。因此，我们的发现建立了一种新型的复杂伤口临床治疗技术。