Centrosome, composed of two centrioles arranged in an orthogonal configuration, is an indispensable cellular organelle for mitosis. 130 years after its discovery, the structural-functional relationship of centrosome is still obscure. Encouraged by the telltale signs of the “Mouse and Magnet experiment”, Paul Schafer pioneered in the research on electromagnetism of centriole with electron microscopy(EM) in the late 1960s. Followed by the decades-long slow progression of the field with sporadic reports indicating the electromagnetisms of mitosis. Piecing together the evidences, we generated a mechanistic model for centrosome function during mitosis, in which centrosome functions as an electronic generator. In particular, the spinal rotations of centrioles transform the cellular chemical energy into cellular electromagnetic energy. The model is strongly supported by multiple experimental evidences. It offers an elegant explanation for the self-organized orthogonal configuration of the two centrioles in a centrosome, that is through the dynamic electromagnetic interactions of both centrioles of the centrosome.

中心体由两个正交排列的中心粒组成，是有丝分裂不可或缺的细胞器。中心体发现 130 年后，中心体的结构-功能关系仍不清楚。受到“老鼠和磁铁实验”的启发，保罗·谢弗在 1960 年代后期率先使用电子显微镜 (EM) 研究中心粒的电磁学。随后是该领域长达数十年的缓慢进展，零星的报告表明有丝分裂的电磁学。将证据拼凑在一起，我们为有丝分裂期间的中心体功能生成了一个机制模型，其中中心体充当电子发生器。特别是，中心粒的脊柱旋转将细胞化学能转化为细胞电磁能。该模型得到了多项实验证据的有力支持。它为中心体中两个中心粒的自组织正交构型提供了一个优雅的解释，即通过中心体两个中心粒的动态电磁相互作用。