Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous particles can effectively enhance the aerosolization performance and bioavailability of drugs. However, the existing methods for preparing porous particles using porogens have several drawbacks, such as the inhomogeneous and uncontrollable pores, drug leakage, and high risk of fragmentation. In this study, a series of cyclodextrin-based metal-organic framework (CD-MOF) particles containing homogenous nanopores were delicately engineered without porogens. Compared with commercial inhalation carrier, CD-MOF showed excellent aerosolization performance because of the homogenous nanoporous structure. The great biocompatibility of CD-MOF in pulmonary delivery was also confirmed by a series of experiments, including cytotoxicity assay, hemolysis ratio test, lung function evaluation, in vivo lung injury markers measurement, and histological analysis. The results of ex vivo fluorescence imaging showed the high deposition rate of CD-MOF in lungs. Therefore, all results demonstrated that CD-MOF was a promising carrier for pulmonary drug delivery. This study may throw light on the nanoporous particles for effective pulmonary administration.

肺部药物递送在生物医学中已引起越来越多的关注，并且多孔颗粒可以有效地增强药物的雾化性能和生物利用度。然而，使用致孔剂制备多孔颗粒的现有方法具有一些缺点，例如孔的不均匀和不可控制，药物渗漏和破碎的高风险。在这项研究中，精心设计了一系列不含致孔剂的，含有均匀纳米孔的环糊精基金属有机骨架（CD-MOF）颗粒。与商用吸入载体相比，CD-MOF具有均匀的纳米孔结构，因此具有出色的雾化性能。CD-MOF在肺部递送中具有巨大的生物相容性，还通过一系列实验得到了证实，包括细胞毒性测定，溶血比测定，体内肺损伤标志物的测定及组织学分析。结果离体荧光成像显示在肺中的CD-MOF的高沉积速率。因此，所有结果表明，CD-MOF是有希望的肺部药物输送载体。这项研究可能会为有效的肺部给药照亮纳米孔颗粒。