A composite modified electrode was prepared based on α-K7P2VW17O62·18H2O (P2W17V), CNTs and AuCo nanoparticles (AuCo NPs), and used as a structurally stable and highly sensitive electrochemical sensor for simultaneous determination of dopamine (DA) and uric acid (UA). The combination of three active components endows the electrode with large specific surface area, high electrical conductivity, and excellent electrochemical activity. The as-prepared modified electrode exhibited impressive electrocatalytic oxidation performance of DA and UA at an optimum working potential (0.172 V vs. Ag/AgCl for DA and 0.288 V vs. Ag/AgCl for UA) with linear detection range from 1.25 × 10−6 to 2.81 × 10−4 M and 0.75 × 10−6 to 1.66 × 10−4 M and the detection limit of 0.15 and 0.25 μM (S/N = 3) for DA and UA, respectively. Additionally, the peak-to-peak separation signals in DPV are 116 mV. The influence of several possible co-existing substances was investigated. The applicability of the method for real samples analysis was tested by determination of DA and UA in human serums. This new sensor holds great promise for sensitive determination of DA and UA in real application. Graphical abstract Graphical abstract

中文翻译：

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基于碳纳米管和金钴纳米粒子修饰的多金属氧酸盐的超灵敏电化学传感器的构建，用于伏安法同时测定多巴胺和尿酸

基于α-K7P2VW17O62·18H2O（P2W17V）、CNTs和AuCo纳米粒子（AuCo NPs）制备了复合修饰电极，作为结构稳定且高灵敏度的电化学传感器同时测定多巴胺（DA）和尿酸（UA） ）。三种活性成分的结合使电极具有大比表面积、高导电性和优异的电化学活性。所制备的修饰电极在最佳工作电位（0.172 V vs. Ag/AgCl DA 和 0.288 V vs. Ag/AgCl UA）下表现出令人印象深刻的 DA 和 UA 电催化氧化性能，线性检测范围为 1.25 × 10− 6 至 2.81 × 10-4 M 和 0.75 × 10-6 至 1.66 × 10-4 M，DA 和 UA 的检测限分别为 0.15 和 0.25 μM（S/N = 3）。此外，DPV 中的峰峰值分离信号为 116 mV。研究了几种可能的共存物质的影响。通过测定人血清中的 DA 和 UA 来测试该方法对实际样品分析的适用性。这种新型传感器有望在实际应用中灵敏测定 DA 和 UA。图形摘要图形摘要