One of prospective methods for immunotherapy of tumors is modulation via immunological checkpoints, specifically, via the PD-1(CD279)/PD-L1(CD274) system. Interactions between tumor cell receptor (CD279) and the ligand on lymphocytes (CD274) leads to lymphocyte inactivation, which allows tumor escape from the immune control. Experiments on C57BL/6 mice with Lewis lung carcinoma demonstrate the possibility of reducing the expression of CD279 and CD274 on the peripheral blood and tumor tissue lymphocytes under the effects of Tussilago farfara L. polysaccharides. This phenomenon can underlie the antitumor and antimetastatic effects of these substances.

中文翻译：

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Tussilago farfara L.多糖对Lewis肺癌小鼠外周血和肿瘤组织淋巴细胞PD-1(CD279)和PD-L1(CD274)表达的影响

肿瘤免疫治疗的一种前瞻性方法是通过免疫检查点进行调节，特别是通过 PD-1(CD279)/PD-L1(CD274) 系统。肿瘤细胞受体 (CD279) 与淋巴细胞上的配体 (CD274) 之间的相互作用导致淋巴细胞失活，从而使肿瘤摆脱免疫控制。在患有Lewis肺癌的C57BL/6小鼠身上的实验证明了在Tussilago farfara L.多糖的作用下降低外周血和肿瘤组织淋巴细胞上CD279和CD274表达的可能性。这种现象是这些物质抗肿瘤和抗转移作用的基础。