Epigenetics research is progressing in basic, pre-clinical and clinical studies using various model systems. Hence, updating the knowledge and integration of biological data emerging from in silico, in vitro and in vivo studies for different epigenetic factors is essential. Moreover, new drugs are being discovered which target various epigenetic proteins, tested in pre-clinical studies, clinical trials and approved by the FDA. It brings distinct challenges as well as opportunities to update the existing HIstome database for implementing and applying enormous data for biomedical research. HISTome2 focuses on the sub-classification of histone proteins as variants and isoforms, post-translational modifications (PTMs) and modifying enzymes for humans (Homo sapiens), rat (Rattus norvegicus) and mouse (Mus musculus) on one interface for integrative analysis. It contains 232, 267 and 350 entries for histone proteins (non-canonical/variants and canonical/isoforms), PTMs and modifying enzymes respectively for human, rat, and mouse. Around 200 EpiDrugs for various classes of epigenetic modifiers, their clinical trial status, and pharmacological relevance have been provided in HISTome2. The additional features like ‘Clustal omega’ for multiple sequence alignment, link to ‘FireBrowse’ to visualize TCGA expression data and ‘TargetScanHuman’ for miRNA targets have been included in the database. The information for multiple organisms and EpiDrugs on a common platform will accelerate the understanding and future development of drugs. Overall, HISTome2 has significantly increased the extent and diversity of its content which will serve as a ‘knowledge Infobase’ for biologists, pharmacologists, and clinicians. HISTome2: The HISTone Infobase is freely available on http://www.actrec.gov.in/histome2/ .

中文翻译：

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HISTome2：组蛋白、多种生物体修饰剂和表皮药物的数据库。

表观遗传学研究正在使用各种模型系统在基础、临床前和临床研究中取得进展。因此，更新知识并整合不同表观遗传因素的计算机、体外和体内研究中出现的生物数据至关重要。此外，针对各种表观遗传蛋白的新药正在被发现，并经过临床前研究、临床试验测试并获得 FDA 批准。更新现有的 Histome 数据库以实施和应用生物医学研究的大量数据带来了独特的挑战和机遇。HISTome2 专注于在一个界面上对人类 (Homo sapiens)、大鼠 (Rattusnorvegicus) 和小鼠 (Mus musculus) 进行组蛋白亚分类，如变体和亚型、翻译后修饰 (PTM) 和修饰酶，以进行综合分析。它包含分别针对人类、大鼠和小鼠的 232、267 和 350 个组蛋白（非规范/变体和规范/亚型）、PTM 和修饰酶条目。HISTome2 中提供了大约 200 种针对各种表观遗传修饰剂的 EpiDrugs、它们的临床试验状态和药理学相关性。数据库中还包括用于多序列比对的“Clustal omega”、用于可视化 TCGA 表达数据的“FireBrowse”链接以及用于 miRNA 目标的“TargetScanHuman”等附加功能。通用平台上的多种生物体和 EpiDrugs 信息将加速药物的理解和未来开发。总体而言，HISTome2 显着增加了其内容的范围和多样性，这将作为生物学家、药理学家和临床医生的“知识信息库”。HISTome2：HISTone 信息库可在 http://www.actrec.gov.in/histome2/ 上免费获取。