Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years regarding the causes and functional relevance of alternative splicing in cancer. Here we discuss the current understanding of the connections between splicing and cancer, with a focus on the most recent findings. We also discuss remaining questions and challenges that must be addressed in order to use our knowledge of splicing to guide the diagnosis and treatment of cancer.

中文翻译：

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选择性剪接和癌症：从转录组的扩展视角中获得的见解、机遇和挑战。

在过去的十年中，人们越来越认识到选择性剪接在癌症病因学中的潜在作用。特别是，RNA测序技术和分析的进步在过去几年中引发了一波关于癌症中选择性剪接的原因和功能相关性的发现。在这里，我们讨论目前对剪接与癌症之间联系的理解，重点关注最新的发现。我们还讨论了必须解决的剩余问题和挑战，以便利用我们的剪接知识来指导癌症的诊断和治疗。