Pioneer factors are transcriptional regulators with the capacity to bind inactive regions of chromatin and induce changes in accessibility that underpin cell fate decisions. The FOXA family of transcription factors is well understood to have pioneer capacity. Indeed, researchers have uncovered numerous examples of FOXA-dependent epigenomic modulation in developmental and disease processes. Despite the presence of FOXA being essential for correct epigenetic patterning, the need for continued FOXA presence postchromatin modulation has been debated. In a recent study in this issue of Genes & Development, Reizel and colleagues (pp. 1039–1050) show that the tissue-specific ablation of FOXA1/2/3 in the adult mouse liver results in the collapse of the epigenetic profile that maintains the hepatic gene expression profile. Thus, FOXA functions as a key, opening regions of chromatin during development, and as a doorstep, maintaining the established euchromatic structure in adult tissue.

中文翻译：

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FoxA因素：染色质关键和门挡是肝脏发育和功能必不可少的。

先锋因子是转录调节因子，具有结合染色质非活性区域并诱导可及性变化的能力，这些改变是细胞命运决定的基础。众所周知，FOXA转录因子家族具有先驱能力。确实，研究人员发现了许多在发育和疾病过程中依赖FOXA的表观基因组调控的例子。尽管FOXA的存在对于正确的表观遗传模式必不可少，但对于染色后调节后继续存在FOXA的需求一直存在争议。在本期《基因与发育》的最新研究中，Reizel及其同事（第1039-1050页）显示，成年小鼠肝脏中FOXA1 / 2/3的组织特异性消融导致表观遗传谱的崩溃，从而维持了肝基因表达谱。因此，FOXA在发育过程中起着关键的染色质开放区域的作用，并作为一个门阶，在成人组织中维持已建立的常色结构。