Countercurrently Operated Reactive Extractor with an Additively Manufactured Enzyme Carrier Structure,Organic Process Research & Development

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Countercurrently Operated Reactive Extractor with an Additively Manufactured Enzyme Carrier Structure
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-08-03 , DOI: 10.1021/acs.oprd.0c00205
Niclas Büscher ₁ , Claas Spille ₂ , John K. Kracht ₁ , Giovanni V. Sayoga ₁ , Ayad W. H. Dawood ₁ , Maria Isabelle Maiwald ₃ , Dirk Herzog ₃ , Michael Schlüter ₂ , Andreas Liese ₁

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Precisely designed structures inserted in hybrid reactors can be used to control multiphase hydrodynamics and to act as a catalyst carrier simultaneously. While numerical simulations with computational fluid dynamics have limitations regarding the complex interactions in multiphase flows, performing experiments using rapid prototyping (RP) offers the possibility of a fast fabrication and verification of tailor-made structures for specific flow characteristics, efficient mass transport, and high conversion rates. In the presented work, the development of a countercurrently operated additively manufactured reactor for the decarboxylation of ferulic acid to 2-methoxy-4-vinylphenol (MVP) along in situ extraction with n-heptane is shown. Here, the use and optimization of periodic open-cell structures (POCSs) as a carrier for the enzyme phenolic acid decarboxylase and a distributor for the extraction phase are targeted. By RP of transparent structures and their examination concerning the induced flow characteristics of colored heptane, a structure could be optimized for the specific reaction system. The additive manufacturing of POCSs and their application in a hybrid countercurrently operated reactor enabled the conversion of FA and a low concentration of the competitively inhibiting product MVP in the reaction phase via efficient in situ extraction via the dispersed heptane phase.

中文翻译：

具有附加制造的酶载体结构的逆流操作反应萃取器

插入混合反应器中的精确设计的结构可用于控制多相流体动力学并同时充当催化剂载体。尽管具有计算流体动力学的数值模拟在多相流中的复杂相互作用方面存在局限性，但使用快速原型（RP）进行实验提供了快速制造和验证量身定制的结构以实现特定的流特性，有效的质量传递和高效率的可能性。转换率。在所提出的工作，对于阿魏酸的脱羧一个逆流操作添加制造反应器的沿显影到2-甲氧基-4-乙烯基苯酚（MVP）在原位与萃取Ñ显示了庚烷。在此，针对周期性开放单元结构（POCS）作为酚酸脱羧酶酶的载体和提取阶段的分配器的使用和优化成为目标。通过透明结构的RP及其有关彩色庚烷的诱导流动特性的检查，可以针对特定的反应体系优化结构。POCSs的添加剂制造以及它们在混合逆流操作反应器应用程序启用FA的转化率和在反应相中的竞争性抑制产品MVP的低浓度通过高效原位萃取经由分散庚烷相。

更新日期：2020-09-20

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