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Prospecting for molecular glues.
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2020-08-03 , DOI: 10.1038/s41589-020-0620-z
Willem den Besten 1 , J Russell Lipford 1
Affiliation  

Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.

中文翻译:

寻求分子胶。

最近的两项研究发现,CDK12抑制剂与CDK12-cyclin K复合物结合,并起分子胶的作用,以稳定与泛素连接酶CUL4-DDB1的相互作用,从而导致cyclin K降解。
更新日期:2020-08-03
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