Abstract

New Cu(II), Ni(II), Zn(II) complexes of a guanylurea ligand were synthesized and their structures were characterized by spectroscopic and analytical methods. The ligand was prepared by the hydrolysis of dicyandiamine in the presence of glacial acetic acid and obtained as acetate salt (HL·OAc). Molecular structure of the ligand and its Cu(II) complex were determined by single crystal X-ray diffraction studies. In the structure of the Cu(II) complex, each Cu(II) ion is four-coordinate with an approximate square planar geometry. The structures of the ligand and its Cu(II) complex were stabilized by hydrogen bond interactions. Antibacterial activity of the complexes was evaluated by single disk method. The complexes exhibit antibacterial activity. The synthesized compounds were screened for their FSds-DNA properties and Zn(II) complex showed higher binding affinity than free ligand and its Cu(II) and Ni(II) complexes.

抽象的

合成了鸟尿素配体的新型Cu（II），Ni（II），Zn（II）配合物，并通过光谱和分析方法对其结构进行了表征。在冰醋酸存在下，通过双氰胺的水解制备配体，并以乙酸盐（HL·OAc）的形式获得。通过单晶X射线衍射研究确定了配体及其Cu（II）配合物的分子结构。在Cu（II）配合物的结构中，每个Cu（II）离子都是四坐标的，具有近似正方形的平面几何形状。配体及其Cu（II）配合物的结构通过氢键相互作用得以稳定。通过单盘法评价复合物的抗菌活性。该复合物表现出抗菌活性。