Adaptation is an important mechanism that causes a decrease in the neural response both in terms of local field potentials (LFP) and spiking activity. We previously showed this reduction effect in the tuning curve of the primary auditory cortex. Moreover, we revealed that a repeated stimulus reduces the neural response in terms of spike-phase coupling (SPC). In the current study, we examined the effect of adaptation on the SPC tuning curve. To this end, employing the phase-locking value (PLV) method, we estimated the spike-LFP coupling. The data was obtained by a simultaneous recording from four single-electrodes in the primary auditory cortex of 15 rats. We first investigated whether the neural system may use spike-LFP phase coupling in the primary auditory cortex to encode sensory information. Secondly, we investigated the effect of adaptation on this potential SPC tuning. Our data showed that the coupling between spikes’ times and the LFP phase in beta oscillations represents sensory information (different stimulus frequencies), with an inverted bell-shaped tuning curve. Furthermore, we showed that adaptation to a specific frequency modulates SPC tuning curve of the adapter and its neighboring frequencies. These findings could be useful for interpretation of feature representation in terms of SPC and the underlying neural mechanism of adaptation.

中文翻译：

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适应调节大鼠初级听觉皮层中的尖峰相位耦合调谐曲线

适应是导致神经反应在局部场电位 (LFP) 和尖峰活动方面降低的重要机制。我们之前在初级听觉皮层的调谐曲线中显示了这种减少效果。此外，我们揭示了重复刺激会降低尖峰相位耦合 (SPC) 方面的神经反应。在当前的研究中，我们检查了适应对 SPC 调谐曲线的影响。为此，我们采用锁相值 (PLV) 方法估计了尖峰-LFP 耦合。这些数据是通过同时记录 15 只大鼠初级听觉皮层中的四个单电极获得的。我们首先研究了神经系统是否可以在初级听觉皮层中使用尖峰-LFP 相位耦合来编码感觉信息。第二，我们研究了适应对这种潜在的 SPC 调整的影响。我们的数据表明，β 振荡中尖峰时间和 LFP 相位之间的耦合代表了感官信息（不同的刺激频率），具有倒钟形调谐曲线。此外，我们展示了对特定频率的适应会调制适配器及其相邻频率的 SPC 调谐曲线。这些发现可能有助于解释 SPC 和潜在的适应神经机制方面的特征表示。我们展示了对特定频率的适应会调制适配器及其相邻频率的 SPC 调谐曲线。这些发现可能有助于解释 SPC 和潜在的适应神经机制方面的特征表示。我们展示了对特定频率的适应会调制适配器及其相邻频率的 SPC 调谐曲线。这些发现可能有助于解释 SPC 和潜在的适应神经机制方面的特征表示。