The Coronavirus‐2019 (COVID‐19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID‐19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point‐of‐care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource‐limited areas, and even in clinical settings. In this article, we summarize the current state of COVID‐19 diagnostic methods and make a case for an all‐in‐one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID‐19 infection. We believe this article will provide insights into the current state of diagnostics for COVID‐19, and promote additional research and tool development that could be exceptionally impactful.

中文翻译：

---

当前冠状病毒的诊断工具 - 从实验室诊断到 COVID-19 的 POC 诊断。


2019 年冠状病毒 (COVID-19) 大流行给全球医疗保健系统带来了巨大压力。对于临床医生来说，通过临床症状区分 COVID-19 与其他急性呼吸道感染具有挑战性，因为感染者会表现出多种症状。有效的护理点 (POC) 诊断工具可以减轻医疗保健系统的压力，保护医疗保健专业人员并支持检疫工作。我们相信可以开发出一种快速、易于使用且廉价的 POC 工具。它可以在家庭、资源有限的地区，甚至在临床环境中使用。在本文中，我们总结了 COVID-19 诊断方法的现状，并提出了一种集成抗体检测、蛋白质检测和血清细胞因子检测来诊断 COVID-19 感染的一体化、高灵敏度 POC 检测方法。我们相信这篇文章将深入了解 COVID-19 的诊断现状，并促进可能产生巨大影响的额外研究和工具开发。