The objective of this study was to determine the pharmacokinetics of tolfenamic acid (TA) following intravenous (IV) administration at doses of 2 and 4 mg/kg in goats. In this study, six healthy goats were used. TA was administered intravenously to each goat at 2 and 4 mg/kg doses in a cross‐over pharmacokinetic design with a 15‐day washout period. Plasma concentrations of TA were analyzed using the high performance liquid chromatography with ultraviolet detector, and pharmacokinetic parameters were assigned by noncompartmental analysis. Following IV administration at dose of 2 mg/kg, area under the concentration–time curve (AUC_0−∞), elimination half‐life (t_1/2ʎz), total clearance (Cl_T) and volume of distribution at steady state (V_dss) were 6.64 ± 0.81 hr^*µg/ml, 1.57 ± 0.14 hr, 0.30 ± 0.04 L h^‐1 kg^‐1 and 0.40 ± 0.05 L/kg, respectively. After the administration of TA at a dose of 4 mg/kg showed prolonged t_1/2ʎz, increased dose‐normalized AUC_0‐∞, and decreased Cl_T. In goats, TA at 4 mg/kg dose can be administered wider dose intervals compared to the 2 mg/kg dose. However, further studies are needed to determine the effect of different doses on the clinical efficacy of TA in goats.

中文翻译：

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剂量对托芬那酸在山羊中的静脉药代动力学的影响。

这项研究的目的是确定在山羊中以2和4 mg / kg的剂量静脉内（IV）施用后的托芬那酸（TA）的药代动力学。在这项研究中，使用了六只健康的山羊。通过交叉药代动力学设计，以15天的洗脱期对每只山羊以2和4 mg / kg剂量静脉内给予TA。使用带有紫外检测器的高效液相色谱法分析TA的血浆浓度，并通过非房室分析指定药代动力学参数。以2 mg / kg的剂量静脉内给药后，浓度-时间曲线下的面积（_{AUC0 -∞}），消除半衰期（t _{1 /2ʎz}），总清除率（Cl _T）和稳态下的分布量（V_dss）分别为6.64±0.81 hr ^* µg / ml，1.57±0.14 hr，0.30±0.04 L h ^-1  kg ^-1和0.40±0.05 L / kg。给予4 mg / kg的TA后，t _{1 /2ʎz}延长，剂量归一化_{AUC0 -∞}增加，Cl _T降低。在山羊中，与2 mg / kg剂量相比，可以更宽的剂量间隔给予4 mg / kg剂量的TA。但是，需要进一步的研究来确定不同剂量对山羊TA的临床疗效的影响。