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Histone H3K9 methylation regulates chronic stress and IL-6-induced colon epithelial permeability and visceral pain.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-08-02 , DOI: 10.1111/nmo.13941
John W Wiley 1 , Ye Zong 2 , Gen Zheng 1 , Shengtao Zhu 2 , Shuangsong Hong 1
Affiliation  

Chronic stress is associated with activation of the HPA axis, elevation in pro‐inflammatory cytokines, decrease in intestinal epithelial cell tight junction (TJ) proteins, and enhanced visceral pain. It is unknown whether epigenetic regulatory pathways play a role in chronic stress–induced intestinal barrier dysfunction and visceral hyperalgesia.

中文翻译:

组蛋白 H3K9 甲基化调节慢性应激和 IL-6 诱导的结肠上皮通透性和内脏疼痛。

慢性压力与 HPA 轴的激活、促炎细胞因子的升高、肠上皮细胞紧密连接 (TJ) 蛋白的减少和内脏疼痛加剧有关。尚不清楚表观遗传调控途径是否在慢性压力诱导的肠道屏障功能障碍和内脏痛觉过敏中起作用。
更新日期:2020-08-02
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