Histone H3K9 methylation regulates chronic stress and IL-6-induced colon epithelial permeability and visceral pain.,Neurogastroenterology & Motility

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Histone H3K9 methylation regulates chronic stress and IL-6-induced colon epithelial permeability and visceral pain.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-08-02 , DOI: 10.1111/nmo.13941
John W Wiley ₁ , Ye Zong ₂ , Gen Zheng ₁ , Shengtao Zhu ₂ , Shuangsong Hong ₁

Affiliation

Chronic stress is associated with activation of the HPA axis, elevation in pro‐inflammatory cytokines, decrease in intestinal epithelial cell tight junction (TJ) proteins, and enhanced visceral pain. It is unknown whether epigenetic regulatory pathways play a role in chronic stress–induced intestinal barrier dysfunction and visceral hyperalgesia.

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