Single-cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: A potential pathway of COVID-19 infection.,Molecular Genetics & Genomic Medicine

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Single-cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: A potential pathway of COVID-19 infection.
Molecular Genetics & Genomic Medicine ( IF 1.5 ) Pub Date : 2020-08-03 , DOI: 10.1002/mgg3.1442
Qiyu He _{1,

2} , Tsz N Mok ₁ , Liang Yun ₃ , Chengbo He ₄ , Jieruo Li ₁ , Jinghua Pan ₁

Affiliation

A novel coronavirus called SARS‐Cov‐2, which shared 82% similarity of genome sequence with SARS‐CoV, was found in Wuhan in late December of 2019, causing an epidemic outbreak of novel coronavirus‐induced pneumonia with dramatically increasing number of cases. Several organs are vulnerable to COVID‐19 infection. Acute kidney injury (AKI) was reported in parts of case‐studies reporting characteristics of COVID‐19 patients. This study aimed at analyzing the potential route of SARS‐Cov‐2 entry and mechanism at cellular level.

中文翻译：

人类肾脏的单细胞RNA测序分析揭示了ACE2受体的存在：ACEV受体19的潜在途径。

2019年12月下旬在武汉发现了一种名为SARS-Cov-2的新型冠状病毒，与SARS-CoV具有82％的基因组序列相似性，导致新型冠状病毒引起的肺炎的流行，病例数急剧增加。多个器官易受COVID-19感染。在部分病例研究中报告了急性肾损伤（AKI），该病例报告了COVID-19患者的特征。这项研究旨在在细胞水平上分析SARS-Cov-2进入的潜在途径和机制。

更新日期：2020-10-12

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