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Inhibitory potential on key enzymes relevant to type II diabetes mellitus and antioxidant properties of the various extracts and phytochemical constituents from Rumex acetosella L.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-03 , DOI: 10.1111/jfbc.13415 Nadire Özenver 1 , Zühal Güvenalp 2 , Ayşe Kuruüzüm-Uz 1 , Lütfiye Ömür Demirezer 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-03 , DOI: 10.1111/jfbc.13415 Nadire Özenver 1 , Zühal Güvenalp 2 , Ayşe Kuruüzüm-Uz 1 , Lütfiye Ömür Demirezer 1
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Type II diabetes mellitus is a common and costly disease worldwide, characterized by hyperglycemia. Alpha (α)‐amylase and α‐glucosidase are important targets in diabetes therapy. Inhibition of these enzymes may lessen hyperglycemia, preventing diabetic complications. Oxidative stress is another factor involved in the disease's etiology. In the present study, we investigated antidiabetic profiles of the various extracts and phytochemicals of Rumex acetosella. Since the plant has been traditionally used for the antidiabetic purposes. α‐amylase and α‐glucosidase inhibitory studies in addition to DPPH•, ABTS•+, 
radical scavenging, and phosphomolybdate antioxidant assays were performed to evaluate the antidiabetic property. Specifically, the ethanol and ethanol‐water extracts remarkably inhibited α‐glucosidase than that of acarbose, unlike their slight/no inhibition on α‐amylase. Convincing α‐glucosidase inhibitory and antioxidant potential of alcohol‐including extracts verified the ethnobotanical use of R. acetosella as an antidiabetic agent.
中文翻译：
对与 II 型糖尿病相关的关键酶的抑制潜力以及酸模各种提取物和植物化学成分的抗氧化特性。
II型糖尿病是世界范围内一种常见且昂贵的疾病，其特征是高血糖。 α ( α )-淀粉酶和α-葡萄糖苷酶是糖尿病治疗的重要靶标。抑制这些酶可以减轻高血糖，预防糖尿病并发症。氧化应激是该疾病病因学的另一个因素。在本研究中，我们研究了酸模的各种提取物和植物化学物质的抗糖尿病特性。由于该植物传统上被用于抗糖尿病目的。除 DPPH•、ABTS•+ 外，还进行α-淀粉酶和α-葡萄糖苷酶抑制研究， 进行自由基清除和磷钼酸盐抗氧化测定来评估抗糖尿病特性。具体而言，乙醇和乙醇水提取物比阿卡波糖显着抑制α-葡萄糖苷酶，这与它们对α-淀粉酶的轻微/无抑制不同。含酒精提取物具有令人信服的α-葡萄糖苷酶抑制和抗氧化潜力，证实了醋酸R. acetosella作为抗糖尿病药物的民族植物学用途。
更新日期：2020-10-11
radical scavenging, and phosphomolybdate antioxidant assays were performed to evaluate the antidiabetic property. Specifically, the ethanol and ethanol‐water extracts remarkably inhibited α‐glucosidase than that of acarbose, unlike their slight/no inhibition on α‐amylase. Convincing α‐glucosidase inhibitory and antioxidant potential of alcohol‐including extracts verified the ethnobotanical use of R. acetosella as an antidiabetic agent.
中文翻译：
对与 II 型糖尿病相关的关键酶的抑制潜力以及酸模各种提取物和植物化学成分的抗氧化特性。
II型糖尿病是世界范围内一种常见且昂贵的疾病，其特征是高血糖。 α ( α )-淀粉酶和α-葡萄糖苷酶是糖尿病治疗的重要靶标。抑制这些酶可以减轻高血糖，预防糖尿病并发症。氧化应激是该疾病病因学的另一个因素。在本研究中，我们研究了酸模的各种提取物和植物化学物质的抗糖尿病特性。由于该植物传统上被用于抗糖尿病目的。除 DPPH•、ABTS•+ 外，还进行α-淀粉酶和α-葡萄糖苷酶抑制研究，
进行自由基清除和磷钼酸盐抗氧化测定来评估抗糖尿病特性。具体而言，乙醇和乙醇水提取物比阿卡波糖显着抑制α-葡萄糖苷酶，这与它们对α-淀粉酶的轻微/无抑制不同。含酒精提取物具有令人信服的α-葡萄糖苷酶抑制和抗氧化潜力，证实了醋酸R. acetosella作为抗糖尿病药物的民族植物学用途。
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