Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4‐positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4‐positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4‐positive neurons.

中文翻译：

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PTEN活性的抑制促进IB4阳性感觉神经元轴突的生长。

创伤性神经损伤已成为常见的临床问题，轴突再生是成功恢复受损神经系统功能的关键过程。在这项研究中，我们发现外周轴突切开术降低了成人感觉神经元中PTEN的表达；然而，它并没有改变IB4阳性感觉神经元中PTEN的表达水平。此外，我们的结果表明，人工抑制PTEN可以显着促进成人感觉轴突再生，包括IB4阳性神经元轴突的生长。因此，我们的结果提供了有力的证据，证明PTEN是成人感觉轴突再生的重要抑制剂，尤其是在IB4阳性神经元中。