Lignans, Monoterpenes and γ‐Pyrone Derivatives from Patrinia scabiosaefolia with Cytotoxic Activity against HCT‐116 Cells,Chemistry & Biodiversity

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Lignans, Monoterpenes and γ‐Pyrone Derivatives from Patrinia scabiosaefolia with Cytotoxic Activity against HCT‐116 Cells
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-10-01 , DOI: 10.1002/cbdv.202000397
Xuan Zhang ₁ , Meng-Jue Rui ₁ , Hong-Tao Xu ₁ , Gui-Xin Chou ₁

Affiliation

One new dihydrobenzofuran neolignan, patrinianeolignan I, two new monoterpenes, 6,7‐dehydrodissectol A and patriniaol A, and a new γ‐pyrone derivative, hydroxymaltol 3‐O‐(6′‐O‐trans‐caffeoyl)‐β‐D‐glucopyranoside, along with fifteen known lignans, eight known monoterpenes, and two known γ‐pyrone derivatives, were isolated from the whole plant of Patrinia scabiosifolia. Their structures were elucidated by 1D‐ and 2D‐NMR and HR‐ESI‐MS analysis. The absolute configuration of patrinianeolignan I was confirmed by circular dichroism (CD) spectrum. All compounds were evaluated in vitro for their cytotoxic activity against HCT‐116 cells. The results showed that compounds patriniaol A and eudesmin exhibited moderate cytotoxicity against HCT‐116 cells with IC50 values of 42.23 μM and 41.92 μM, respectively.

中文翻译：

来自腐竹的木脂素、单萜和 γ-吡喃酮衍生物对 HCT-116 细胞具有细胞毒活性

一种新的二氢苯并呋喃新木脂素，patrinianeolignan I，两种新的单萜，6,7-dehydrodissectol A 和patriniaol A，以及一种新的γ-吡喃酮衍生物，羟基麦芽酚 3-O-(6'-O-trans-caffeoyl)-β-D-吡喃葡萄糖苷以及十五种已知的木脂素、八种已知的单萜和两种已知的 γ-吡喃酮衍生物，是从腐竹的整株植物中分离出来的。通过一维和二维核磁共振和 HR-ESI-MS 分析阐明了它们的结构。patrinianeolignan I 的绝对构型由圆二色性 (CD) 光谱证实。所有化合物都在体外评估了它们对 HCT-116 细胞的细胞毒活性。结果表明，化合物patriniaol A和eudesmin对HCT-116细胞表现出中等的细胞毒性，IC50值分别为42.23 μM和41.92 μM。

更新日期：2020-10-01

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