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Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
Advanced Science ( IF 14.3 ) Pub Date : 2020-08-02 , DOI: 10.1002/advs.201901996 Ziqi Zhao 1 , Ziwei Shang 2 , Zilton Vasconcelos 3 , Chunfeng Li 4 , Yisheng Jiang 1 , Shulong Zu 5, 6 , Jingyi Zhang 2 , Fengchao Wang 2 , Li Yao 2 , Jae U Jung 7 , Patricia Brasil 8 , Maria Elisabeth Moreira 3 , Cheng-Feng Qin 9 , Tara Kerin 10 , Karin Nielsen-Saines 10 , Genhong Cheng 5, 6, 11 , Xiaohui Zhang 2 , Zhiheng Xu 1, 12
Advanced Science ( IF 14.3 ) Pub Date : 2020-08-02 , DOI: 10.1002/advs.201901996 Ziqi Zhao 1 , Ziwei Shang 2 , Zilton Vasconcelos 3 , Chunfeng Li 4 , Yisheng Jiang 1 , Shulong Zu 5, 6 , Jingyi Zhang 2 , Fengchao Wang 2 , Li Yao 2 , Jae U Jung 7 , Patricia Brasil 8 , Maria Elisabeth Moreira 3 , Cheng-Feng Qin 9 , Tara Kerin 10 , Karin Nielsen-Saines 10 , Genhong Cheng 5, 6, 11 , Xiaohui Zhang 2 , Zhiheng Xu 1, 12
Affiliation
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Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience‐dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood.
中文翻译：
寨卡病毒感染导致小鼠和儿童多种神经功能和行为出现不同程度的缺陷
寨卡病毒 (ZIKV) 因其与先天性寨卡综合征的因果关系而已演变成全球健康威胁。孕妇感染 ZIKV 可能会导致儿童出现一系列异常。在巴西的研究中，对一大批围产期接触寨卡病毒的儿童进行了跟踪，并发现了一系列神经发育异常。同时，研究表明，当代 ZIKV 毒株（而不是亚洲祖先毒株）感染小鼠新生儿大脑可导致小头畸形和各种神经功能异常。这些缺陷包括社交互动和抑郁缺陷、学习和记忆受损，以及成年小鼠和未来儿童群体中存在的严重运动缺陷。重要的是，尽管出生后感染的小鼠大脑没有明显的异常大脑结构，但这些小鼠仍然表现出视觉皮层功能、回路组织和经验依赖性可塑性的显着损伤。因此，该研究建议，应特别关注寨卡病毒感染母亲所生的所有儿童，筛查儿童时期的异常行为和感觉功能。
更新日期：2020-09-23
中文翻译：
寨卡病毒感染导致小鼠和儿童多种神经功能和行为出现不同程度的缺陷
寨卡病毒 (ZIKV) 因其与先天性寨卡综合征的因果关系而已演变成全球健康威胁。孕妇感染 ZIKV 可能会导致儿童出现一系列异常。在巴西的研究中，对一大批围产期接触寨卡病毒的儿童进行了跟踪，并发现了一系列神经发育异常。同时，研究表明，当代 ZIKV 毒株（而不是亚洲祖先毒株）感染小鼠新生儿大脑可导致小头畸形和各种神经功能异常。这些缺陷包括社交互动和抑郁缺陷、学习和记忆受损，以及成年小鼠和未来儿童群体中存在的严重运动缺陷。重要的是，尽管出生后感染的小鼠大脑没有明显的异常大脑结构，但这些小鼠仍然表现出视觉皮层功能、回路组织和经验依赖性可塑性的显着损伤。因此，该研究建议，应特别关注寨卡病毒感染母亲所生的所有儿童，筛查儿童时期的异常行为和感觉功能。
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