Rational Design of Functional Peptide-Gold Hybrid Nanomaterials for Molecular Interactions.,Advanced Materials

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Rational Design of Functional Peptide-Gold Hybrid Nanomaterials for Molecular Interactions.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-08-02 , DOI: 10.1002/adma.202000866
Xiaohu Liu _{1,

2} , Qingwen Zhang _{1,

2} , Wolfgang Knoll ₃ , Bo Liedberg ₄ , Yi Wang _{1,

2}

Affiliation

Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing‐related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide–AuNP‐based bio‐nano‐technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide–gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide–gold nanomaterials with functional properties are discussed along with future challenges and opportunities.

中文翻译：

用于分子相互作用的功能性肽-金杂化纳米材料的合理设计。

金纳米颗粒（AuNPs）由于出色的光学性能已在生物传感相关开发中广泛使用了数十年。作为新近实现的功能性生物分子，肽是有希望替代特定分子相互作用的抗体，受体和底物的候选物。肽和AuNPs都很健壮，并且可以以较低的成本轻松合成。因此，基于肽-AuNP的生物纳米技术方法引起了越来越多的兴趣，尤其是在分子靶向，细胞成像，药物递送和治疗领域。在这些领域有许多出色的作品被报道：展示新颖的思想，探索新的目标以及促进先进的诊断和治疗技术。重要的是，其中一些也已被用来解决实际的实际问题，特别是在偏远和特权较低的地区。这项贡献致力于肽-金杂化纳米材料在各种分子相互作用中的应用，尤其是在生物传感/诊断和细胞靶向/成像中，以及在开发高活性抗菌/防污涂层策略方面。讨论了具有功能特性的合理设计的肽金纳米材料以及未来的挑战和机遇。

更新日期：2020-09-15

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