Bacterial infections play a disruptive and hidden role in male reproductive failure. Different kinds of bacteria are often able to interfere with reproductive function in both sexes and lead to infertility. In this study, to further evaluate the role of bacterial infections in male reproduction we provided an extensive overview of so far researches investigating the effects of bacterial infections on male fertility. We searched Medline, PubMed, Scopus and Google scholar databases to identify the potentially relevant studies on bacterial infections and their implications in male infertility. All the bacteria included in this article have negative effects on the male reproductive function; however, there is ample evidence to blame bacteria such as Escherichia coli, Chlamydia trachomatis, Ureaplasma, Mycoplasma and Staphylococcus aureus for reduced fertility and deterioration of sperm parameters. More studies are needed to clarify the molecular mechanisms by which different bacteria exert their detrimental effects on male reproductive system. Getting more insight into probable mechanisms, would significantly facilitate the production of new, advanced, and effective remedies in the future. In view of all evidence, we strongly suggest increasing awareness among people and considering screening programs for patients seeking fertility both to avoid transmission and to improve fertility outcomes among them.

细菌感染在男性生殖失败中起着破坏性和隐藏的作用。不同种类的细菌通常能够干扰两性的生殖功能并导致不育。在这项研究中，为了进一步评估细菌感染在男性生殖中的作用，我们广泛概述了迄今为止调查细菌感染对男性生育能力影响的研究。我们搜索了 Medline、PubMed、Scopus 和 Google 学者数据库，以确定有关细菌感染及其对男性不育的影响的潜在相关研究。本文包含的所有细菌对男性生殖功能都有负面影响；然而，有充分的证据可以归咎于细菌，如大肠杆菌、沙眼衣原体、脲原体、支原体和金黄色葡萄球菌降低生育能力和精子参数恶化。需要更多的研究来阐明不同细菌对男性生殖系统产生不利影响的分子机制。更深入地了解可能的机制，将极大地促进未来新的、先进的和有效的补救措施的产生。鉴于所有证据，我们强烈建议提高人们的认识，并考虑对寻求生育的患者进行筛查，以避免传播并改善他们之间的生育结果。