Perturbations of proteostatic mechanisms and mitochondrial decline during ageing and neurodegenerative diseases are well-established. Nevertheless, only a handful of interventions boosting proteostasis and mitochondrial function have been shown to delay ageing while therapies against neurodegeneration are still unavailable. Increasing evidence links the function of proteostatic mechanisms with each other and with the mitochondrial network. Tracing of this complex crosstalking network might lead to effective anti-ageing or neurodegenerative disease-modifying approaches. In this review we present evidence on the crosstalk of proteostatic mechanisms with mitochondria and discuss how incorporating this knowledge in future studies may help us develop more efficacious interventions against ageing and neurodegeneration.

在衰老和神经退行性疾病过程中，蛋白质稳态机制的扰动和线粒体衰退已得到公认。然而，只有少数促进蛋白质稳态和线粒体功能的干预措施被证明可以延缓衰老，而对抗神经变性的疗法仍然不可用。越来越多的证据将蛋白质稳态机制的功能相互联系起来，并与线粒体网络联系起来。追踪这种复杂的串扰网络可能会导致有效的抗衰老或神经退行性疾病改善方法。在这篇综述中，我们提供了关于线粒体与蛋白质稳态机制的串扰的证据，并讨论了如何在未来的研究中结合这些知识可以帮助我们开发更有效的干预措施来对抗衰老和神经变性。