Abstract The synchronization of diagnosis and treatment is a new trend in cancer treatment. Photoacoustic imaging (PAI) and photothermal therapy (PTT) are recognized as one of the perfect combinations. The autocatalytic polymerization of selenium/polypyrrole (Se@PPy) nanocomposites with a wide-absorption band at near-infrared region (NIR, 800 nm) has been developed in this paper. The wide optical absorption characteristics enable Se@PPy nanocomposites to achieve multi-spectral PAI. Ex vivo experiments show desirable photoacoustic ability of the Se@PPy nanocomposites at wavelengths ranging from 700 nm to 900 nm, which is better than that of commercial indocyanine green (ICG). Se@PPy nanocomposites have high photothermal conversion efficiency up to 36.3% as well as excellent photo-thermal stability. In vitro cytotoxicity test demonstrates that the Se@PPy nanocomposites have good bio-safety. Furthermore, the feasibility of Se@PPy nanocomposites for enhancing multi-spectral PAI guided PTT was verified on 4T1 tumor-bearing nude mice. Our results indicate that Se@PPy nanocomposites could be used as an effective theranostic agent for near-infrared light-mediated PAI and PTT of tumor.

中文翻译：

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硒/聚吡咯纳米复合材料的自催化聚合作为功能治疗诊断剂用于肿瘤的多光谱光声成像和光热治疗

摘要 诊疗同步是癌症治疗的新趋势。光声成像（PAI）和光热疗法（PTT）被公认为完美的组合之一。本文开发了在近红外区域（NIR，800 nm）具有宽吸收带的硒/聚吡咯（Se@PPy）纳米复合材料的自催化聚合。广泛的光吸收特性使 Se@PPy 纳米复合材料能够实现多光谱 PAI。离体实验表明，Se@PPy 纳米复合材料在 700 nm 至 900 nm 的波长范围内具有理想的光声能力，优于商业吲哚菁绿（ICG）。Se@PPy 纳米复合材料具有高达 36.3% 的高光热转换效率以及优异的光热稳定性。体外细胞毒性试验表明Se@PPy纳米复合材料具有良好的生物安全性。此外，Se@PPy 纳米复合材料用于增强多光谱 PAI 引导的 PTT 的可行性在 4T1 荷瘤裸鼠身上得到验证。我们的结果表明，Se@PPy 纳米复合材料可用作近红外光介导的肿瘤 PAI 和 PTT 的有效治疗诊断剂。