When applied to a radiosynthesis, a microscale approach can help to save precursor and improve yields. Thus, a 5–10 μL microscale method based on a concentration procedure was developed and applied to the radiosynthesis of [¹⁸F]FET and [¹⁸F]fallypride. In spite of using an amount of precursor ca. 100 times smaller, radiochemical yields were comparable or even higher than those reported in literature. Because of the very low reaction volumes, the possible effects of concentrated dose of activity and carrier fluoride were also investigated.

中文翻译：

---

一种基于浓度的18F亲核取代微观方法及其在[18F] FET和[18F]氟吡咯一锅辐射合成中的测试。

当应用于放射合成时，微尺度方法可以帮助节省前驱物并提高产率。因此，开发了一种基于浓缩程序的5–10μL微量方法，并将其应用于[ ¹⁸ F] FET和[ ¹⁸ F]氟吡脲的放射性合成。尽管使用了一定数量的前体。放射化学收率比文献报道的小100倍，甚至可比甚至更高。由于反应体积非常小，因此还研究了浓缩剂量的活性物质和载体氟化物的可能影响。