Abstract

Glycosaminoglycans are important complex carbohydrates that are used in a number of pharmaceutical products. Because glycosaminoglycans are obtained by isolation from biological materials, their pharmaceutical analysis before therapeutic use is of paramount importance. Due to their versatility, wide applicability, non-destructiveness, and in particular the possibility of obtaining a “fingerprint” clearly proving the given chemical specie, spectrometric methods are one of the essential methods used for these analyzes. This review is focused on significant spectrometric methods used in the pharmaceutical analysis of glycosaminoglycans. The advantages and prospects of individual methods (NMR spectrometry, infrared and Raman spectrometry, UV/Vis spectrometry, spectrofluorimetry, chemiluminescence, and circular dichroism) used and methodological aspects of the analysis are discussed. The possibilities of further development and application of spectral methods in the discussed area are outlined.

Graphic abstract

中文翻译：

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糖胺聚糖药物分析中的光谱方法：最新技术

摘要

糖胺聚糖是许多药物产品中使用的重要复合碳水化合物。由于糖胺聚糖是通过从生物材料中分离获得的，因此在治疗用途之前对其进行药物分析至关重要。由于它们的通用性，广泛的适用性，无损性，尤其是获得清晰证明给定化学物种的“指纹”的可能性，光谱法是用于这些分析的基本方法之一。这篇综述的重点是用于糖胺聚糖药物分析的重要光谱方法。各种方法的优点和前景（NMR光谱，红外和拉曼光谱，UV / Vis光谱，荧光光谱，化学发光，和圆二色性）以及分析的方法论方面进行了讨论。概述了在所讨论的领域中进一步开发和应用光谱方法的可能性。

图形摘要