We studied histophysiology of the adrenal medulla in adult (70-day-old) male Wistar rats developmentally exposed to low doses of endocrine disruptor DDT. It was found that exposure to DDT during the prenatal and postnatal ontogeny decelerated the development of the adrenal medulla and reduced the synthesis of tyrosine hydroxylase, the rate-liming enzyme of catecholamine synthesis, in chromaffin cells, which led to a decrease in epinephrine secretion into the blood.

中文翻译：

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产前和产后暴露于内分泌干扰物滴滴涕后大鼠肾上腺髓质组织生理学的变化

我们研究了发育暴露于低剂量内分泌干扰物 DDT 的成年（70 天大）雄性 Wistar 大鼠肾上腺髓质的组织生理学。研究发现，在产前和产后个体发育过程中接触 DDT 会减慢肾上腺髓质的发育并减少酪氨酸羟化酶（儿茶酚胺合成的限速酶）的合成，从而导致肾上腺素分泌减少。血液。