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Experimental Model of Cirrhosis of the Liver
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-07-01 , DOI: 10.1007/s10517-020-04899-2
N S Tropskaya 1 , E A Kislyakova 1 , I G Vilkova 1 , O S Kislitsyna 1 , Yu V Gurman 1 , T S Popova 1 , V N Baimatov 2
Affiliation  

A new model of cirrhosis of the liver was created in experiment on 30 rats. Over 3 weeks, experimental animals in addition to the standard diet daily intragastrically received corn oil in combination with intragastric administration of acetaminophen in a dose of 500 mg/day. High-fat load in combination with acetaminophen over 3 weeks led to the development of focal biliary cirrhosis.

中文翻译:

肝硬化实验模型

以30只大鼠为实验对象建立了新的肝硬化模型。超过 3 周,实验动物除了每天的标准饮食外,还胃内接受玉米油联合对乙酰氨基酚的胃内给药,剂量为 500 毫克/天。高脂肪负荷与对乙酰氨基酚相结合超过 3 周导致局灶性胆汁性肝硬化的发展。
更新日期:2020-07-01
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