Background: Benzo[b]furan derivatives are oxygen-containing heterocyclic compounds consisting of fused benzene and furan rings and are present in a large number of natural and non-natural compounds. This class of compounds has a wide spectrum of biological activities, such as antiarrhythmic, anticancer, inflammatory, antioxidant, antimicrobial, and antiviral. Furthermore, benzo[b]furan derivatives have also been applied in various areas, such as organic electroluminescence device materials and organic dyes, photosensitizing material, organic synthesis as building blocks or intermediates.

Because of a broad range of applicability, the synthesis of benzo[b]furan derivative has drawn great attention of chemists and many studies on the synthesis of this class of compounds have been reported recently. This review will give an overview of benzo[b]furan preparation based on studies dating back to the year 2012.

Objective: In this review, recent development in the synthesis of benzo[b]furans are discussed. There has been increasingly new methodologies for the construction of benzo[b]furans skeleton to improve efficiency or develop environmentally friendly procedures. In some studies, reaction mechanisms were also outlined.

Conclusion: Many methods for the synthesis of benzo[b]furans have been reported recently. Most of them involve cyclization or cycloisomerization processes. Unquestionably, more imaginative strategies for the construction of benzo[b]furan skeleton will be established in the near future. Application of known methods to natural products or drug synthesis, on industrial scale for the synthesis of economically or medicinally important benzo[ b]furans will probably be paid attention to.

背景：苯并[b]呋喃衍生物是由稠合的苯和呋喃环组成的含氧杂环化合物，并以大量天然和非天然化合物形式存在。这类化合物具有广泛的生物学活性，例如抗心律不齐，抗癌，抗炎，抗氧化剂，抗微生物和抗病毒。此外，苯并[b]呋喃衍生物也已应用于各种领域，例如有机电致发光器件材料和有机染料，光敏材料，有机合成作为结构单元或中间体。

由于广泛的适用性，苯并[b]呋喃衍生物的合成引起了化学家的极大关注，最近已经报道了许多关于合成这类化合物的研究。这项审查将基于可追溯至2012年的研究，概述苯并[b]呋喃的制备方法。

目的：在这篇综述中，讨论了苯并[b]呋喃合成的最新进展。建造苯并[b]呋喃骨架的新方法越来越多，以提高效率或开发环保程序。在一些研究中，还概述了反应机理。

结论：最近已报道了许多合成苯并[b]呋喃的方法。它们大多数涉及环化或环异构化过程。毫无疑问，在不久的将来，将建立更具想象力的苯并[b]呋喃骨架构造策略。在工业规模上将已知方法应用于天然产物或药物合成中以合成经济上或医学上重要的苯并[b]呋喃可能会受到关注。